Description

tert-Butyl 5-Bromopyrimidine-2-carboxylate is a high-purity, versatile pyrimidine derivative used as a key synthetic intermediate in advanced organic chemistry. This compound is critical for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized pyrimidine cores into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that incorporate brominated pyrimidine motifs.
• Material Science: Serves as a precursor for creating functional organic materials, such as ligands for catalysts or components in organic electronic devices.
• Chemical Synthesis: Enables Suzuki-Miyaura and other cross-coupling reactions, facilitating the introduction of diverse functional groups at the 5-position of the pyrimidine ring.
• Academic & R&D: A valuable reagent for medicinal chemistry programs and methodological studies in heterocyclic and organobromine chemistry.

Basic Information

Product Name	tert-Butyl 5-Bromopyrimidine-2-carboxylate
CAS No.	955885-59-3
Molecular Formula	C9H11BrN2O2
Molecular Weight	259.10 g/mol
Synonyms	5-Bromo-2-pyrimidinecarboxylic acid 1,1-dimethylethyl ester; 2-Pyrimidinecarboxylic acid, 5-bromo-, 1,1-dimethylethyl ester; 5-Bromopyrimidine-2-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-2-pyrimidinecarboxylate; 5-Bromo-2-(tert-butoxycarbonyl)pyrimidine; TBBC; t-Butyl 5-bromopyrimidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromopyrimidine-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and consistent performance in critical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.