Description

Fmoc-Asp(Otbu)-Ser(Psi-Me,Mepro)-Oh is a specialized, protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and high-fidelity construction of complex peptides, particularly those containing challenging sequences or requiring specific post-translational modifications. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential assembly of custom peptide chains.
• Pharmaceutical Research: For the development and scale-up of novel peptide-based drug candidates targeting various diseases.
• Bioconjugation: Serving as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Chemical Biology Probes: Incorporation into peptides used as tools to study enzyme function, protein-protein interactions, and cellular pathways.
• Peptide Library Production: Used in combinatorial chemistry to generate diverse peptide libraries for high-throughput screening.
• Academic Research: Enabling fundamental studies in peptide chemistry, structure-activity relationships (SAR), and biomimetics.

Basic Information

Product Name	Fmoc-Asp(Otbu)-Ser(Psi-Me,Mepro)-Oh
CAS No.	955048-92-7
Molecular Formula	C33H44N2O9
Molecular Weight	612.71 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-aspartyl-N-[(2S)-1-methoxy-1-oxopropan-2-yl]-O-methyl-L-serinamide; Fmoc-Asp(OtBu)-Ser(ψMe,Mepro)-OH; Fmoc-L-Asp(OtBu)-L-Ser[ψ(Me,MePro)]-OH; Fmoc-Asp(OtBu)-Ser[ψ(CH3COOCH3)]-OH; Protected Fmoc-Asp-Ser dipeptide; Fmoc-Asp(OtBu)-Ser(ψMe,Mepro) building block
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Otbu)-Ser(Psi-Me,Mepro)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and cGMP starting material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon or nitrogen) after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.