Description

Fmoc-Leu-Thr(Psime,Mepro)-Oh is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over amino acid side-chain reactivity during the construction of complex peptides. It is primarily utilized in pharmaceutical R&D for the synthesis of peptide-based drug candidates, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptides, particularly in Fmoc-based strategies.
• Pharmaceutical Research & Development: Used in the discovery and development of novel therapeutic peptides targeting various diseases.
• Peptide Library Construction: Enables the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Bioconjugation & Labeling: Serves as a precursor for creating site-specifically modified peptides for diagnostic or targeting applications.
• Academic & Institutional Research: Employed in biochemical studies to investigate protein-protein interactions and enzyme mechanisms.
• Custom Peptide Manufacturing: An essential raw material for contract research and manufacturing organizations (CROs/CMOs) producing GMP-grade peptides.

Basic Information

Product Name	Fmoc-Leu-Thr(Psime,Mepro)-Oh
CAS No.	955048-89-2
Molecular Formula	C31H40N2O8S
Molecular Weight	600.73 g/mol
Synonyms	Fmoc-Leu-Thr(Psi(Me,Me)pro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucyl-O-[1-(1-methylethyl)-2-methyl-1-propen-1-yl]-L-threonine; Fmoc-L-leucyl-O-(1-isopropyl-2-methyl-1-propenyl)-L-threonine; Fmoc-Leu-Thr[Psi(Me,Me)Pro]-OH; Fmoc-Leu-Thr(PsiMe,Mepro)-OH; Fmoc-Leu-Thr[Psi(Me,Mepro)]-OH; Protected Fmoc-Leu-Thr dipeptide
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Thr(Psime,Mepro)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and pre-clinical applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.