Description

1-(4-Difluoromethoxy-3-Methoxyphenyl)Ethylamine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluoromethoxy-substituted aromatic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including potential candidates for central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical Development: Serves as a critical material for producing compounds for pharmacological and toxicological evaluation.
• Chemical Synthesis: Acts as a versatile amine component in amide coupling and reductive amination reactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals.

Basic Information

Product Name	1-(4-Difluoromethoxy-3-Methoxyphenyl)Ethylamine
CAS No.	954263-76-4
Molecular Formula	C10H13F2NO2
Molecular Weight	217.21 g/mol
Synonyms	1-(4-(Difluoromethoxy)-3-methoxyphenyl)ethan-1-amine; α-Methyl-4-(difluoromethoxy)-3-methoxybenzylamine; 1-[4-(Difluoromethoxy)-3-methoxyphenyl]ethylamine; 4-(Difluoromethoxy)-3-methoxy-α-methylbenzylamine; (1-(4-(Difluoromethoxy)-3-methoxyphenyl)ethyl)amine; 954263-76-4; Benzenemethanamine, 4-(difluoromethoxy)-3-methoxy-α-methyl-
EINECS	Contact for details

Quality Control

Our 1-(4-Difluoromethoxy-3-Methoxyphenyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.