Description

3-(3-Trifluoromethyl-Phenoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, fluorinated piperidine derivative that serves as a critical advanced pharmaceutical intermediate (API intermediate) in modern drug discovery and development. Its molecular architecture, featuring a trifluoromethylphenoxy group and a protected carboxylic acid, makes it a versatile building block for constructing complex bioactive molecules. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers focused on creating novel therapeutics, particularly in central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for CNS-targeting small molecules.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethyl and piperidine motifs.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	3-(3-Trifluoromethyl-Phenoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	954228-08-1
Molecular Formula	C17H22F3NO3
Molecular Weight	345.36 g/mol
Synonyms	tert-Butyl 3-[3-(trifluoromethyl)phenoxy]piperidine-1-carboxylate; 1-Boc-3-(3-trifluoromethylphenoxy)piperidine; 3-(3-(Trifluoromethyl)phenoxy)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(3-trifluoromethylphenoxy)piperidine; N-Boc-3-(3-trifluoromethylphenoxy)piperidine; 954228-08-1; 3-(3-Trifluoromethylphenoxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(3-Trifluoromethyl-Phenoxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent ISO 9001 quality management systems, ensuring batch-to-batch consistency and traceability. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.