Description

4-(6-Chloro-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research institutions and pharmaceutical manufacturers engaged in developing novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final molecular structure of target APIs, requiring stringent purity standards.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and pharmacological assays.

Basic Information

Product Name	4-(6-Chloro-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	954227-75-9
Molecular Formula	C14H20ClN3O3
Molecular Weight	313.78 g/mol
Synonyms	tert-Butyl 4-[(6-chloropyrimidin-4-yl)oxy]piperidine-1-carboxylate; 1-Boc-4-(6-chloro-4-pyrimidinyloxy)piperidine; 4-(6-Chloro-4-pyrimidinyloxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(6-Chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(6-chloropyrimidin-4-yloxy)piperidine; 4-(6-Chloro-4-pyrimidinyloxy)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(6-chloropyrimidin-4-yloxy)piperidine
EINECS	Contact for details

Quality Control

Our 4-(6-Chloro-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.