Description

1-(4-(2-Chloropyrimidin-4-Yl)Piperazin-1-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a chloropyrimidine core linked to a piperazine acetamide moiety. This compound is valued for its role as a critical building block in the synthesis of targeted small-molecule therapeutics, particularly kinase inhibitors. It is essential for research and development chemists and process scale-up teams in the pharmaceutical, biotechnology, and fine chemical industries seeking reliable, high-quality intermediates for complex API synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Biochemical Research: Used as a scaffold or building block in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Process Chemistry & Scale-Up: Serves as a critical raw material for the development and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the life sciences sector.
• Academic Research: Utilized in university and institutional labs for chemical biology and drug discovery projects.

Basic Information

Product Name	1-(4-(2-Chloropyrimidin-4-Yl)Piperazin-1-Yl)Ethanone
CAS No.	954226-92-7
Molecular Formula	C10H12ClN5O
Molecular Weight	253.69 g/mol
Synonyms	1-[4-(2-Chloropyrimidin-4-yl)piperazin-1-yl]ethanone; 1-(4-(2-Chloropyrimidin-4-yl)piperazin-1-yl)ethan-1-one; 2-Chloro-4-(1-acetylpiperazin-4-yl)pyrimidine; 2-Chloro-4-(4-acetylpiperazin-1-yl)pyrimidine; 954226-92-7; Ethanone, 1-[4-(2-chloro-4-pyrimidinyl)-1-piperazinyl]-; 1-(4-(2-Chloro-4-pyrimidinyl)-1-piperazinyl)ethanone
EINECS	Contact for details

Quality Control

Our 1-(4-(2-Chloropyrimidin-4-Yl)Piperazin-1-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.