Description

(S)-3-Cyclopentyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral cyclopentyl side chain and an Fmoc-protected amine. This compound matters as a critical, structurally-defined building block for the synthesis of complex peptides and peptidomimetics, enabling the development of novel bioactive molecules. Pharmaceutical researchers and fine chemical manufacturers need it for applications in drug discovery, particularly in creating constrained peptide libraries and investigating structure-activity relationships (SAR) for therapeutic targets.

Application

• Peptide Synthesis Building Block: Used as a specialized, non-proteinogenic amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediate: Serves as a key chiral intermediate in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and central nervous system (CNS) disorders.
• Peptidomimetic Design: Incorporated into peptide backbones to introduce conformational constraints and enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified peptides for studying enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Combinatorial Chemistry: A valuable component in generating diverse chemical libraries for high-throughput screening (HTS) against novel biological targets.

Basic Information

Product Name	(S)-3-Cyclopentyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid
CAS No.	954225-72-0
Molecular Formula	C₂₇H₃₁NO₄
Molecular Weight	433.54 g/mol
Synonyms	Fmoc-(S)-3-Cyclopentyl-β-homoalanine; (S)-3-Cyclopentyl-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyclopentyl-L-β-homoalanine; Fmoc-Cpa(3)-OH; Fmoc-3-Cyclopentyl-DL-β-homoalanine (mixture); Nα-Fmoc-3-cyclopentyl-L-β-homoalanine; BOC Sciences Brand Name: BBL-BB-01500335
EINECS	Contact for details

Quality Control

Our (S)-3-Cyclopentyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.