Description

3-(2,4-Difluoro-Phenoxy)-Azetidine is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system substituted with a difluorophenoxy group. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluorophenoxy moiety can contribute to enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a sophisticated ligand scaffold in organometallic chemistry for creating novel catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique thermal or chemical resistance properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and biological pathways due to its ability to mimic natural substrates.

Basic Information

Product Name	3-(2,4-Difluoro-Phenoxy)-Azetidine
CAS No.	954225-05-9
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	3-(2,4-Difluorophenoxy)azetidine; Azetidine, 3-(2,4-difluorophenoxy)-; 954225-05-9; 3-(2,4-Difluorophenoxy)azetidine; 2,4-Difluoro-3-azetidinyloxybenzene; 3-(2,4-Difluoro-phenoxy)-azetidine; 3-(2,4-Difluorophenoxy)azetidine (Azetidine Derivative)
EINECS	Contact for details

Quality Control

Our 3-(2,4-Difluoro-Phenoxy)-Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.