Description

2-Chloro-4-(3,4-Difluoro-Phenyl)-Pyrimidine is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its core value lies in its versatile chemical structure, which serves as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for medicinal chemists and process development scientists engaged in creating novel active ingredients, where its specific substitution pattern enables targeted molecular modifications.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the pyrimidine core contributes to biological activity.
• Material Science Research: Serves as a precursor for the synthesis of specialized organic electronic materials and ligands for catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-4-(3,4-Difluoro-Phenyl)-Pyrimidine
CAS No.	954218-48-5
Molecular Formula	C10H5ClF2N2
Molecular Weight	226.61 g/mol
Synonyms	2-Chloro-4-(3,4-difluorophenyl)pyrimidine; 4-(3,4-Difluorophenyl)-2-chloropyrimidine; 2-Chloro-4-(3,4-difluorophenyl)pyrimidine; Pyrimidine, 2-chloro-4-(3,4-difluorophenyl)-; 954218-48-5; 2-Chloro-4-(3,4-difluorophenyl)pyrimidine (CAS 954218-48-5)
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(3,4-Difluoro-Phenyl)-Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.