Description

2-Chloro-4-(3-Trifluoromethyl-Phenyl)-Pyrimidine is a high-value pyrimidine derivative, a crucial heterocyclic building block in advanced organic synthesis. Its core value lies in its trifluoromethyl and chloro substituents, which are key pharmacophores for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-4-(3-Trifluoromethyl-Phenyl)-Pyrimidine
CAS No.	954217-22-2
Molecular Formula	C11H6ClF3N2
Molecular Weight	258.62 g/mol
Synonyms	2-Chloro-4-[3-(trifluoromethyl)phenyl]pyrimidine; 4-(3-Trifluoromethylphenyl)-2-chloropyrimidine; 2-Chloro-4-(3-trifluoromethylphenyl)pyrimidine; 2-Chloro-4-(α,α,α-trifluoro-m-tolyl)pyrimidine; 954217-22-2; Pyrimidine, 2-chloro-4-[3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(3-Trifluoromethyl-Phenyl)-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.