Description

tert-Butyl (6-(Hydroxymethyl)Pyrimidin-4-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine core and protected amine functionality. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring reliable, high-quality building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Organic Synthesis: Used in medicinal chemistry for the construction of complex heterocyclic molecules and structure-activity relationship (SAR) studies.
• Research & Development: Serves as a crucial reagent in academic and industrial R&D for novel drug candidate development.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Bioconjugation Chemistry: The hydroxymethyl group provides a handle for further functionalization and linker attachment in prodrug design.

Basic Information

Product Name	tert-Butyl (6-(Hydroxymethyl)Pyrimidin-4-Yl)Carbamate
CAS No.	954097-20-2
Molecular Formula	C10H15N3O3
Molecular Weight	225.25 g/mol
Synonyms	Boc-6-(hydroxymethyl)pyrimidin-4-amine; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-6-pyrimidinemethanol; 6-(Hydroxymethyl)-N-Boc-pyrimidin-4-amine; tert-Butyl N-[6-(hydroxymethyl)pyrimidin-4-yl]carbamate; 4-(Boc-amino)-6-(hydroxymethyl)pyrimidine; 6-(Hydroxymethyl)pyrimidin-4-yl-carbamic acid tert-butyl ester; (6-(Hydroxymethyl)pyrimidin-4-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (6-(Hydroxymethyl)Pyrimidin-4-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP principles for pharmaceutical intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.