Description

4-Methoxy-3-(2,2,2-trifluoroethoxy)aniline is a specialized aromatic amine derivative featuring both methoxy and trifluoroethoxy substituents, making it a valuable fluorinated building block. This compound matters for its role as a key intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate this unique trifluoroethoxy-aniline motif into novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoroethoxy group enhances compound efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer Chemistry: Employed in the creation of specialty polymers and coatings, where its aromatic amine functionality can be used to introduce cross-linking sites or modify material properties.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing novel fluorinated dyes and pigments with enhanced color fastness and solubility characteristics.
• Research & Development: Essential for medicinal chemistry and process chemistry research in both academic and industrial settings for exploring new chemical entities.

Basic Information

Product Name	4-Methoxy-3-(2,2,2-trifluoroethoxy)aniline
CAS No.	953744-38-2
Molecular Formula	C9H10F3NO2
Molecular Weight	221.18 g/mol
Synonyms	3-(2,2,2-Trifluoroethoxy)-4-methoxyaniline; 4-Methoxy-3-(2,2,2-trifluoroethoxy)benzenamine; 4-Amino-2-methoxy-1-(2,2,2-trifluoroethoxy)benzene; 1-Methoxy-2-amino-4-(2,2,2-trifluoroethoxy)benzene; Aniline, 4-methoxy-3-(2,2,2-trifluoroethoxy)-; CAS 953744-38-2; TFEA Aniline Derivative
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(2,2,2-trifluoroethoxy)aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, extended exposure to light should be avoided.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.