Description

6-Bromo-2-Chloro-8-Fluoroquinazoline is a high-purity, multi-halogenated quinazoline derivative, a crucial advanced pharmaceutical intermediate. Its unique halogen substitution pattern makes it a versatile and valuable scaffold for constructing complex molecules in medicinal chemistry. This compound is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries, particularly those focused on kinase inhibitor development and novel active ingredient synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of targeted cancer therapeutics, especially tyrosine kinase inhibitors (TKIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides and fungicides.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic Research: Employed in university and institutional labs for heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	6-Bromo-2-Chloro-8-Fluoroquinazoline
CAS No.	953039-25-3
Molecular Formula	C8H3BrClFN2
Molecular Weight	261.48 g/mol
Synonyms	6-Bromo-2-chloro-8-fluoroquinazoline; 8-Fluoro-6-bromo-2-chloroquinazoline; Quinazoline, 6-bromo-2-chloro-8-fluoro-; 2-Chloro-6-bromo-8-fluoroquinazoline; 6-Bromo-2-chloro-8-fluoro-quinazoline; 953039-25-3; BCFQ
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Chloro-8-Fluoroquinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.