Description

1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. This compound matters because it serves as a versatile intermediate for introducing the sulfonamide pharmacophore, a key structural motif in modern medicinal chemistry. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of small molecule drug candidates, particularly those targeting enzyme inhibition.
• Sulfonamide Library Synthesis: Used in combinatorial and parallel chemistry for generating diverse compound libraries for high-throughput screening.
• Protease Inhibitor Development: Essential building block for creating potential inhibitors of various proteases (e.g., thrombin, factor Xa).
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Agrochemical Research: Intermediate in the development of new herbicides and fungicides containing sulfonamide groups.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique properties.

Basic Information

Item	Details
Product Name	1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride
CAS No.	952424-09-8
Molecular Formula	C9H8ClNO3S
Molecular Weight	245.68 g/mol
Synonyms	7-Isoquinolinesulfonyl chloride, 1,2,3,4-tetrahydro-1-oxo-; Tetrahydro-1-oxoisoquinoline-7-sulfonyl chloride; 1,2,3,4-Tetrahydro-1-oxo-7-isoquinolinesulfonyl chloride; 7-(Chlorosulfonyl)-3,4-dihydro-1(2H)-isoquinolinone; 1-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride; 1,2,3,4-Tetrahydroisoquinolin-1-one-7-sulfonyl chloride; 7-Chlorosulfonyl-3,4-dihydro-1(2H)-isoquinolinone
EINECS	Contact for details

Quality Control

Our 1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.