Description

2,4(1H,3H)-Pyrimidinedione, 3-Benzoyl-1-(4-Chlorobutyl)-5-(2-Fluoro-3-Pyridinyl)- is a high-purity, synthetically derived pyrimidinedione derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or key intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly for neurological and metabolic disease targets.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical intermediate in the commercial-scale production of complex, fluorinated pyrimidine-based APIs.
• Biochemical Research: Potential use as a tool compound or probe for studying enzyme inhibition or receptor binding in biochemical assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 3-Benzoyl-1-(4-Chlorobutyl)-5-(2-Fluoro-3-Pyridinyl)-
CAS No.	952403-29-1
Molecular Formula	C20H17ClFN3O3
Molecular Weight	401.82 g/mol
Synonyms	3-Benzoyl-1-(4-chlorobutyl)-5-(2-fluoropyridin-3-yl)pyrimidine-2,4(1H,3H)-dione; 1-(4-Chlorobutyl)-3-benzoyl-5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione; 952403-29-1; 3-Benzoyl-1-(4-chlorobutyl)-5-(2-fluoro-3-pyridinyl)uracil; Fluorinated Pyrimidinedione Derivative; API Intermediate 952403-29-1
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with the standards expected by the pharmaceutical and fine chemical industries, and we can support development under various quality regimes, including cGMP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants and storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.