Description

Methyl 4-[4-(tert-Butyl)Phenyl]-6-(2-Methoxy-2-Oxoethyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders or metabolic diseases.
• Drug Discovery Research: Serves as a versatile scaffold for medicinal chemistry programs, enabling the exploration of structure-activity relationships (SAR) in new chemical entities.
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	Methyl 4-[4-(tert-Butyl)Phenyl]-6-(2-Methoxy-2-Oxoethyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	952183-65-2
Molecular Formula	C20H26N2O6
Molecular Weight	390.43 g/mol
Synonyms	Methyl 4-(4-tert-butylphenyl)-6-(2-methoxy-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbomethoxy-4-(4-tert-butylphenyl)-6-(methoxycarbonylmethyl)-3,4-dihydropyrimidin-2(1H)-one; 952183-65-2; 4-(4-tert-Butylphenyl)-6-(2-methoxy-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester; Dihydropyrimidinone derivative; DHPM derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, identity, and impurity profiles. While typically supplied as a high-purity research grade, we can discuss specifications aligned with GMP guidelines for development and commercial-scale projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.