Description

Methyl 4-(4-Chlorophenyl)-6-(2-Methoxy-2-Oxoethyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate CAS NO 952183-64-1 is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyrimidine class. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise molecular structure that enables targeted drug development. It is primarily required by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydropyrimidinone (DHPM) based APIs, which are explored for a range of therapeutic applications.
• Antiviral Drug Research: Serves as a core scaffold in the development of potential antiviral and anticancer agents due to its bioactive tetrahydropyrimidine core.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the 4-chlorophenyl moiety for biological activity.
• Chemical Biology & Medicinal Chemistry: Employed as a versatile building block for creating focused libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP guidelines.

Basic Information

Item	Details
Product Name	Methyl 4-(4-Chlorophenyl)-6-(2-Methoxy-2-Oxoethyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	952183-64-1
Molecular Formula	C16H17ClN2O5
Molecular Weight	352.77 g/mol
Synonyms	Methyl 4-(4-chlorophenyl)-6-(2-methoxy-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbomethoxy-4-(4-chlorophenyl)-6-(methoxycarbonylmethyl)-3,4-dihydropyrimidin-2(1H)-one; 4-(4-Chlorophenyl)-6-(2-methoxy-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester; DHPM derivative; Biginelli reaction product; Tetrahydropyrimidine-5-carboxylate ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-Chlorophenyl)-6-(2-Methoxy-2-Oxoethyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.