Description

Esketamine Hydrochloride CAS NO 952154-79-9 is the S-enantiomer of ketamine hydrochloride, a high-purity pharmaceutical active ingredient (API) with significant therapeutic potential. Its primary value lies in its potent and rapid-acting antidepressant and anesthetic properties, offering a targeted mechanism of action. This compound is essential for pharmaceutical manufacturers and research institutions engaged in developing and producing advanced neuropsychiatric treatments and anesthetic formulations.

Application

• Pharmaceutical API: Core active ingredient in antidepressant nasal sprays (e.g., for treatment-resistant depression).
• Anesthetic Agent: Used in surgical and procedural sedation due to its dissociative anesthetic properties.
• Neuropsychiatric Research: Critical compound for preclinical and clinical studies on depression, PTSD, and other CNS disorders.
• Analytical Reference Standard: Serves as a high-purity standard for quality control and method development in analytical laboratories.
• Formulation Development: Used in R&D for developing new drug delivery systems and dosage forms.
• Veterinary Medicine: Applied in veterinary anesthesia and pain management protocols.

Basic Information

Product Name	Esketamine Hydrochloride
CAS No.	952154-79-9
Molecular Formula	C13H17Cl2NO • HCl
Molecular Weight	274.19 g/mol
Synonyms	(S)-Ketamine Hydrochloride; (2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride; S(+)-Ketamine HCl; Esketamine HCl; L-Ketamine Hydrochloride; JNJ-54135419; SPRAVATO® (Brand Name API)
EINECS	Contact for details

Quality Control

Our Esketamine Hydrochloride is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Production adheres to cGMP (current Good Manufacturing Practice) guidelines, ensuring batch-to-batch consistency and traceability. Comprehensive testing is performed, including identity, purity, and impurity profiling via advanced analytical techniques. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.