Description

4-Hydroxy Propofol is a key chemical intermediate of significant importance in the synthesis of advanced pharmaceutical compounds. This compound matters for its role in developing and producing high-purity active pharmaceutical ingredients (APIs), particularly in the anesthetic and sedative drug class. Pharmaceutical manufacturers and advanced research laboratories require this high-quality intermediate to ensure the efficacy and safety of their final drug products.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of Propofol and its related analogs, a widely used intravenous anesthetic agent.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in research and development for new sedative-hypnotic medications.
• Chemical Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of pharmaceutical formulations.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of anesthetic drugs.
• Academic & Institutional Research: Utilized in pharmacological studies to understand metabolic pathways and structure-activity relationships (SAR).

Basic Information

Product Name	4-Hydroxy Propofol
CAS No.	1988-10-9
Molecular Formula	C12H18O2
Molecular Weight	194.27 g/mol
Synonyms	2,6-Diisopropylphenol, 4-Hydroxy Derivative; 4-Hydroxy-2,6-diisopropylphenol; 4-Hydroxy-2,6-bis(1-methylethyl)phenol; Propofol Impurity A; Propofol Related Compound A; 1-Hydroxy-2,6-diisopropylbenzene; 4-OH Propofol; Phenol, 4-hydroxy-2,6-bis(1-methylethyl)-
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propofol is manufactured under strict quality management systems to meet the rigorous standards required for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and GC. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider using an inert gas blanket (e.g., nitrogen or argon) and ensure the container is kept in a dark environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.