Description

R-(-)-Isoflurane CAS NO 133098-04-1 is the enantiomerically pure form of the widely used inhalation anesthetic, isoflurane. This specific stereoisomer is of significant interest in pharmaceutical research and development for studying stereoselective pharmacological effects and metabolism. It is primarily utilized by research institutions, pharmaceutical companies, and advanced chemical synthesis laboratories. The high purity and defined stereochemistry make it a critical reagent for developing and understanding next-generation anesthetic agents.

Application

• Pharmaceutical Research & Development: Key starting material or reference standard for investigating the stereospecific activity, pharmacokinetics, and toxicity profiles of anesthetic agents.
• Preclinical Studies: Used in animal model research to study the differential effects of anesthetic enantiomers on the central nervous system and other organ systems.
• Metabolic Pathway Analysis: Employed to elucidate enantioselective metabolism and biotransformation pathways in pharmacological studies.
• Analytical Reference Standard: Serves as a high-purity standard for chiral analytical methods, including HPLC and GC, to quantify isoflurane enantiomers.
• Advanced Chemical Synthesis: Used as a chiral building block or intermediate in the synthesis of more complex, stereochemically defined pharmaceutical compounds.
• Mechanism of Action Studies: Critical for research aimed at understanding the specific molecular interactions at neuronal receptors (e.g., GABAA, NMDA) mediated by a single enantiomer.

Basic Information

Product Name	R-(-)-Isoflurane
CAS No.	133098-04-1
Molecular Formula	C3H2ClF5O
Molecular Weight	184.49 g/mol
Synonyms	(R)-Isoflurane; (-)-Isoflurane; (R)-1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; (R)-2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; Forane (enantiomer); Aerrane (enantiomer); (R)-2-Chloro-1,1,1-trifluoro-2-(difluoromethoxy)ethane
EINECS	Contact for details

Quality Control

Our R-(-)-Isoflurane is manufactured and handled under strict quality systems to ensure exceptional enantiomeric purity and chemical integrity. Each batch is subjected to comprehensive analytical testing, including chiral chromatography (GC/HPLC), optical rotation measurement, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and all relevant specifications is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, ideally at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 99.0%
Enantiomeric Excess (ee)	≥ 99.0%
Optical Rotation [α]D20	- Contact for details -
Related Substances (GC)	≤ 0.5% total
Water Content (KF)	≤ 0.1%
Residue on Evaporation	≤ 0.01%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.