Description

Levomedetomidine is the pharmacologically inactive enantiomer of the sedative and analgesic agent medetomidine. This high-purity chiral compound is of critical importance for pharmaceutical research and development, particularly in the study of stereoselective drug action and metabolism. It serves as a key reference standard and intermediate for analytical method development, quality control, and the synthesis of novel active pharmaceutical ingredients (APIs). Industries requiring this material include pharmaceutical R&D, contract manufacturing organizations (CMOs), and academic research institutions focused on anesthesiology and chiral chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of the active enantiomer in drug substances and finished products.
• Chiral Intermediate: Serves as a critical building block in the synthesis and research of stereochemically pure pharmaceutical compounds.
• Metabolic Studies: Employed in preclinical and clinical research to investigate the stereoselective metabolism, pharmacokinetics, and excretion profiles of medetomidine-related compounds.
• Analytical Method Development: Essential for developing and validating chiral separation methods, such as High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE).
• Quality Control & Assurance: Utilized in pharmaceutical QC laboratories to ensure the enantiomeric purity and consistency of active pharmaceutical ingredients (APIs).
• Pharmacological Research: Acts as a negative control in receptor-binding assays and studies to elucidate the specific activity of the active (dexmedetomidine) enantiomer.

Basic Information

Product Name	Levomedetomidine
CAS No.	1061620-92-5
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	(S)-Medetomidine; (-)-Medetomidine; L-Medetomidine; 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; Levomedetomidine Hydrochloride (salt form); Dexmedetomidine Impurity; Medetomidine Related Compound; Chiral Medetomidine Isomer
EINECS	Contact for details

Quality Control

Our Levomedetomidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.