Description

2,2,2-Trifluoro-n-Phenylacetimidic Acid Benzyl Ester is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role in introducing the trifluoroacetimidate moiety, a key functional group for constructing complex nitrogen-containing molecules with enhanced metabolic stability and lipophilicity. Pharmaceutical, agrochemical, and advanced material research laboratories require this high-purity intermediate for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Ligand & Catalyst Preparation: Serves as a precursor for nitrogen-donor ligands used in transition metal catalysis for cross-coupling and other organic transformations.
• Material Science: Incorporated into polymers and advanced materials to impart specific chemical resistance, surface energy, or optical properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and labeled compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Scale-up: Supplied for contract research organizations (CROs) and development and manufacturing organizations (CDMOs) engaged in custom synthesis projects.

Basic Information

Product Name	2,2,2-Trifluoro-n-Phenylacetimidic Acid Benzyl Ester
CAS No.	952057-61-3
Molecular Formula	C15H12F3NO2
Molecular Weight	295.26 g/mol
Synonyms	Benzyl 2,2,2-trifluoro-N-phenylacetimidate; N-Phenyl-2,2,2-trifluoroacetimidic Acid Benzyl Ester; Benzyl Trifluoroacetimidate, N-Phenyl-; Phenyl(2,2,2-trifluoro-1-iminoethoxy)methylbenzene; 2,2,2-Trifluoroacetophenone Imine Benzyl Ether; TFABE; Glycine, 2,2,2-trifluoro-N-phenyl-, benzyl ester
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-Phenylacetimidic Acid Benzyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.