Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-(Methylamino)Hexanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, enabling the precise introduction of a methylamino-functionalized lysine side chain into peptide chains under standard Fmoc solid-phase peptide synthesis (SPPS) conditions. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs developing novel therapeutic peptides, peptide-drug conjugates, and biochemical probes where controlled modification of side-chain functionality is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the site-specific incorporation of Nε-methylated lysine analogs into peptide sequences.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting GPCRs, enzymes, and protein-protein interactions.
• Peptide-Drug Conjugates (PDCs): Enables the construction of linker regions or functionalized peptide backbones for targeted drug delivery systems.
• Biochemical Probe Synthesis: Facilitates the creation of labeled or modified peptides for studying enzyme mechanisms, protein interactions, and cellular signaling pathways.
• Post-Translational Modification (PTM) Mimetics: Essential for synthesizing peptides that mimic naturally occurring methylated lysine residues, crucial for epigenetics and histone research.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-(Methylamino)Hexanoic Acid
CAS No.	951695-86-6
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	Fmoc-Lys(Me)-OH; Fmoc-Nε-Methyl-L-lysine; Nα-Fmoc-Nε-methyl-L-lysine; Fmoc-Nε-Methyllysine; (S)-2-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)-6-(methylamino)hexanoic acid; Fmoc-Lys(N-Me)-OH; Nε-Methyl-Nα-Fmoc-L-lysine; Fmoc-MeLys-OH
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-(Methylamino)Hexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.