Description

n-(Piperidin-4-Yl)-4-(Trifluoromethyl)Pyrimidin-2-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a well-defined chemical structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its piperidine and trifluoromethylpyrimidine motifs.
• Process Chemistry & Scale-Up: Employed in route scouting and the development of robust, scalable synthetic processes for GMP manufacturing.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a reference standard for analytical method development and validation.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary molecules for client-specific R&D projects.

Basic Information

Product Name	n-(Piperidin-4-Yl)-4-(Trifluoromethyl)Pyrimidin-2-Amine Dihydrochloride
CAS No.	951004-19-6
Molecular Formula	C10H14Cl2F3N5
Molecular Weight	316.16 g/mol
Synonyms	4-(Trifluoromethyl)-2-(4-piperidinylamino)pyrimidine dihydrochloride; 2-Piperidin-4-ylamino-4-trifluoromethyl-pyrimidine dihydrochloride; 4-(Trifluoromethyl)-N-(piperidin-4-yl)pyrimidin-2-amine dihydrochloride; 951004-19-6; 4-(4-Piperidinylamino)-2-(trifluoromethyl)pyrimidine dihydrochloride; N-(4-Piperidinyl)-4-(trifluoromethyl)-2-pyrimidinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our n-(Piperidin-4-Yl)-4-(Trifluoromethyl)Pyrimidin-2-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.