Description

4-[1-Cyclohexyl-4-(4-Fluorophenyl)-1H-Imidazol-5-Yl]-2-Pyrimidinaminedihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 950912-80-8. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing targeted therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The imidazole-pyrimidine core structure makes it valuable for research into potential kinase inhibitors for oncology and inflammatory diseases.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	4-[1-Cyclohexyl-4-(4-Fluorophenyl)-1H-Imidazol-5-Yl]-2-Pyrimidinaminedihydrochloride
CAS No.	950912-80-8
Molecular Formula	C19H21FN6 • 2HCl
Molecular Weight	425.33 g/mol (Free base)
Synonyms	4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride; 2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, dihydrochloride; 950912-80-8; UNII-9K3F8S6F1C; 9K3F8S6F1C; CHEMBL3186473; BDBM50121371; AKOS015915889
EINECS	Contact for details

Quality Control

Our 4-[1-Cyclohexyl-4-(4-Fluorophenyl)-1H-Imidazol-5-Yl]-2-Pyrimidinaminedihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.