Description

2-(Piperidin-4-Yloxy)Pyrimidine Dihydrochloride is a high-purity, versatile chemical intermediate with significant utility in advanced organic synthesis. This compound is particularly valued for its role as a key building block in the research and development of novel pharmaceutical candidates, especially within kinase inhibitor programs. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to introduce specific piperidine-pyrimidine motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of small molecule drug candidates, particularly kinase inhibitors targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing routes.
• Biochemical Tool Compound: Utilized in the development of probes and assay components for biological target validation and screening.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-(Piperidin-4-Yloxy)Pyrimidine Dihydrochloride
CAS No.	950649-19-1
Molecular Formula	C9H14N3O·2HCl
Molecular Weight	267.15 g/mol (free base: 180.23 g/mol)
Synonyms	2-((Piperidin-4-yl)oxy)pyrimidine dihydrochloride; 2-(4-Piperidyloxy)pyrimidine dihydrochloride; 4-(Pyrimidin-2-yloxy)piperidine dihydrochloride; Pyrimidine, 2-(4-piperidinyloxy)-, dihydrochloride; UNII-7H5R6N8Q8I; 950649-19-1; 2-Piperidin-4-yloxy-pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Piperidin-4-Yloxy)Pyrimidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.