Description

3-(Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its pyrrolidine and pyrimidine functional groups. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing therapeutics in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The pyrrolidine core structure makes it valuable for research into inhibitors targeting various protease enzymes.
• Kinase Inhibitor Synthesis: Employed in the construction of heterocyclic compounds designed to modulate kinase activity for potential therapeutic applications.
• Chemical Biology Probes: Serves as a starting material for creating specialized molecular tools used to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	3-(Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	950649-08-8
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	1-Boc-3-(2-pyrimidinylamino)pyrrolidine; tert-Butyl 3-[(pyrimidin-2-yl)amino]pyrrolidine-1-carboxylate; 3-(2-Pyrimidinylamino)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-3-(pyrimidin-2-ylamino)pyrrolidine; 3-(Pyrimidin-2-ylamino)pyrrolidine-1-carboxylic acid tert-butyl ester; Pyrrolidine, 3-[(2-pyrimidinyl)amino]-, 1-(1,1-dimethylethyl) ester; Boc-3-(2-Pyrimidinylamino)pyrrolidine
EINECS	Contact for details

Quality Control

Our 3-(Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect the material from moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.