Description

tert-Butyl Methyl 2-(5-Bromopyrimidin-2-Yl)Malonate is a high-purity, functionalized malonate ester derivative featuring a bromopyrimidine moiety. This compound serves as a versatile and critical building block in advanced organic synthesis, particularly for constructing complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent for creating functional polymers and advanced organic materials.
• Chemical Biology: Employed in the synthesis of probes and labeled compounds for biochemical and pharmacological studies.
• Custom Synthesis: A valuable starting material for contract research organizations (CROs) and fine chemical manufacturers performing bespoke synthesis.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical reactions.

Basic Information

Product Name	tert-Butyl Methyl 2-(5-Bromopyrimidin-2-Yl)Malonate
CAS No.	948594-79-4
Molecular Formula	C14H17BrN2O4
Molecular Weight	357.20 g/mol
Synonyms	2-(5-Bromopyrimidin-2-yl)malonic acid 1-tert-butyl 3-methyl ester; 1-tert-Butyl 3-methyl 2-(5-bromopyrimidin-2-yl)propanedioate; Methyl tert-butyl 2-(5-bromopyrimidin-2-yl)malonate; Propanedioic acid, 2-(5-bromo-2-pyrimidinyl)-, 1-(1,1-dimethylethyl) 3-methyl ester; 948594-79-4; tert-Butyl methyl (5-bromopyrimidin-2-yl)malonate
EINECS	Contact for details

Quality Control

Our tert-Butyl Methyl 2-(5-Bromopyrimidin-2-Yl)Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.