Description

2-Amino-3-Chloro-4-Fluoronitrobenzene is a high-purity, multi-functional halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring strategically placed amino, chloro, fluoro, and nitro substituents, makes it an indispensable intermediate for creating complex, high-value compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for synthesizing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Dye and Pigment Manufacturing: Serves as a building block for synthesizing specialized azo dyes and high-performance pigments, contributing to color fastness and thermal stability.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers where specific halogen and nitro group interactions are required for electronic properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl and heteroaryl structures.
• Chemical Research & Development: A valuable reagent for method development and exploring new reaction pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	2-Amino-3-Chloro-4-Fluoronitrobenzene
CAS No.	948014-34-4
Molecular Formula	C6H4ClFN2O2
Molecular Weight	190.56 g/mol
Synonyms	3-Chloro-4-fluoro-2-nitroaniline; 2-Nitro-3-chloro-4-fluoroaniline; 1-Amino-2-chloro-3-fluoro-4-nitrobenzene; 4-Fluoro-3-chloro-2-nitroaniline; Benzenamine, 3-chloro-4-fluoro-2-nitro-; 3-Chloro-4-fluoro-2-nitrobenzenamine; 2-Amino-3-chloro-4-fluoronitrobenzene (alternate numbering)
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3-Chloro-4-Fluoronitrobenzene is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. Our products are developed to meet the exacting standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.