Description

5-Bromo-2-(Cyclobutylamino)-Pyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine core functionalized with bromine and a cyclobutylamino group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, particularly within oncology and antiviral research pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Kinase Inhibitor Research: Serves as a core scaffold or precursor for the design and synthesis of novel protein kinase inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug potency and selectivity.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development for global biopharma clients.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	5-Bromo-2-(Cyclobutylamino)-Pyrimidine
CAS No.	947534-33-0
Molecular Formula	C8H10BrN3
Molecular Weight	228.09 g/mol
Synonyms	5-Bromo-2-(cyclobutylamino)pyrimidine; 2-(Cyclobutylamino)-5-bromopyrimidine; 5-Bromo-N-cyclobutylpyrimidin-2-amine; 947534-33-0; Pyrimidine, 5-bromo-2-(cyclobutylamino)-; 5-Bromo-2-cyclobutylaminopyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Cyclobutylamino)-Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this light-sensitive material.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.