Description

Difluoro-(4-Iodo-Phenoxy)-Acetic Acid Ethyl Ester is a high-purity fluorinated and iodinated aromatic building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for introducing both fluorine and iodine functional groups into target molecules, enabling the development of novel compounds with modified electronic and steric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new active ingredients and for use in cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine atoms to modulate metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides where the difluoroacetic ester and iodoaryl motifs are required.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in advanced polymers and catalytic systems.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes, leveraging the iodine as a potential handle for further modification or labeling.

Basic Information

Product Name	Difluoro-(4-Iodo-Phenoxy)-Acetic Acid Ethyl Ester
CAS No.	947533-64-4
Molecular Formula	C10H9F2IO3
Molecular Weight	342.08 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(4-iodophenoxy)acetate; 2-(4-Iodophenoxy)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl [Difluoro(4-iodophenoxy)acetate]; Difluoro(4-iodophenoxy)acetic Acid Ethyl Ester; 4-Iodophenyl 2,2-Difluoro-2-ethoxy-2-oxoethyl Ether; 947533-64-4; AI3-31800
EINECS	Contact for details

Quality Control

Every batch of Difluoro-(4-Iodo-Phenoxy)-Acetic Acid Ethyl Ester is produced and analyzed under strict quality management protocols to ensure consistency and high purity for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.