Description

(4-Fmoc-Amino-Tetrahydrothiopyran-4-Yl)-Acetic Acid CAS NO 946727-62-4 is a specialized, high-purity Fmoc-protected amino acid derivative featuring a tetrahydrothiopyran scaffold. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of unique structural motifs and sulfur-containing heterocycles into peptide chains. It is essential for research and development chemists in pharmaceutical discovery, agrochemical research, and advanced materials science who require sophisticated, custom amino acid analogs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the incorporation of constrained, sulfur-containing amino acid residues into novel peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of peptide-based therapeutics, including enzyme inhibitors, receptor agonists/antagonists, and diagnostic agents.
• Chemical Biology & Proteomics: Serves as a tool compound for studying protein-protein interactions and for creating peptide probes and labeled biomolecules.
• Agrochemical Development: Employed in the synthesis of bioactive peptide mimetics for potential crop protection agents.
• Material Science: A precursor for creating functionalized polymers and advanced organic materials with specific chemical functionalities.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for the production of complex, non-natural peptides and conjugates under GMP or non-GMP conditions.

Basic Information

Product Name	(4-Fmoc-Amino-Tetrahydrothiopyran-4-Yl)-Acetic Acid
CAS No.	946727-62-4
Molecular Formula	C23H25NO4S
Molecular Weight	411.52 g/mol
Synonyms	4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]tetrahydro-2H-thiopyran-4-acetic acid; Fmoc-Amino-Tetrahydrothiopyran-4-Acetic Acid; 4-(Fmoc-amino)tetrahydro-2H-thiopyran-4-acetic acid; 4-[(Fmoc-amino)methyl]tetrahydro-2H-thiopyran-4-carboxylic acid (tautomer); Fmoc-Thp(Ac)-OH; (4-Fmoc-aminothian-4-yl)acetic acid; Fmoc-protected thiopyranyl glycine derivative
EINECS	Contact for details

Quality Control

Our (4-Fmoc-Amino-Tetrahydrothiopyran-4-Yl)-Acetic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development projects requiring material aligned with ICH guidelines and can discuss custom synthesis under controlled environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (nitrogen or argon) after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.