Description

3-Fluoro-4-(2-Fluorophenoxy)Aniline is a high-purity, specialized aromatic amine derivative featuring a unique difluorophenoxy substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic diamines used in the production of high-performance polyimides for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or chain modifier in the synthesis of specialty polymers, such as polyamides and polyurethanes, to impart specific thermal or chemical resistance properties.
• Dye & Pigment Manufacturing: Employed in the synthesis of complex, high-value azo dyes and pigments that require specific light-fastness and color properties.
• Cross-Coupling Reactions: The aniline functionality makes it a suitable substrate for Buchwald-Hartwig amination and other palladium-catalyzed cross-coupling reactions to create complex biaryl ethers and amines.

Basic Information

Product Name	3-Fluoro-4-(2-Fluorophenoxy)Aniline
CAS No.	946699-01-0
Molecular Formula	C12H9F2NO
Molecular Weight	221.20 g/mol
Synonyms	4-Amino-2-fluoro-1-(2-fluorophenoxy)benzene; 2-Fluoro-4-amino-1-(2-fluorophenoxy)benzene; Benzenamine, 3-fluoro-4-(2-fluorophenoxy)-; 3-Fluoro-4-(2-fluorophenoxy)benzenamine; 2,2'-Difluorodiphenyl Ether-4-amine
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(2-Fluorophenoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for scale-up and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and strong oxidizing agents. For long-term storage, consider under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.