Description

4-(2,4-Difluorophenoxy)-3-(Trifluoromethyl)Aniline is a high-purity, multi-fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its unique structure, featuring both phenoxy and aniline functionalities with strategically placed fluorine atoms, makes it a critical intermediate for developing novel active compounds. This product is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to create molecules with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging fluorine's effects on biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with unique properties.
• Chemical Biology & Proteomics: Employed as a linker or tagging reagent in the development of chemical probes and affinity labels for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	4-(2,4-Difluorophenoxy)-3-(Trifluoromethyl)Aniline
CAS No.	946697-82-1
Molecular Formula	C13H8F5NO
Molecular Weight	289.20 g/mol
Synonyms	3-(Trifluoromethyl)-4-(2,4-difluorophenoxy)aniline; 4-(2,4-Difluorophenoxy)-3-(trifluoromethyl)benzenamine; 1-Amino-4-(2,4-difluorophenoxy)-3-(trifluoromethyl)benzene; Benzenamine, 4-(2,4-difluorophenoxy)-3-(trifluoromethyl)-; 4-(2,4-Difluorophenoxy)-alpha,alpha,α-trifluoro-m-toluidine
EINECS	Contact for details

Quality Control

Our 4-(2,4-Difluorophenoxy)-3-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to light, air, or moisture should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.