Description

4-Fluoro-2-Methylphenylthiourea is a specialized organic building block featuring a thiourea moiety substituted with a fluorinated methylphenyl group. This compound matters for its role as a key intermediate in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries seeking to introduce specific fluorine-containing pharmacophores or functional groups into their target compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and environmental stability.
• Material Science: Acts as a monomer or cross-linking agent in the preparation of specialty polymers and resins with unique thermal or chemical resistance properties.
• Chemical Synthesis: Employed in organic synthesis as a versatile reagent for constructing heterocyclic compounds, such as thiazoles and imidazoles, which are common scaffolds in medicinal chemistry.
• Ligand & Catalyst Development: Utilized in the preparation of thiourea-based ligands for metal catalysis or organocatalysis, facilitating asymmetric synthesis.
• Dye & Pigment Intermediate: Functions as a building block for synthesizing specialized dyes and pigments, particularly those requiring sulfur and fluorine components for specific color fastness or properties.

Basic Information

Product Name	4-Fluoro-2-Methylphenylthiourea
CAS No.	946612-94-8
Molecular Formula	C8H9FN2S
Molecular Weight	184.23 g/mol
Synonyms	1-(4-Fluoro-2-methylphenyl)-2-thiourea; N-(4-Fluoro-2-methylphenyl)thiourea; Thiourea, N-(4-fluoro-2-methylphenyl)-; 4-Fluoro-o-tolylthiourea; 2-Methyl-4-fluorophenylthiourea; (4-Fluoro-2-methylphenyl)thiourea; 4-Fluoro-2-methylphenyl-thiourea; CAS 946612-94-8
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Methylphenylthiourea is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.