Description

Boc-D-Hyp-Oh CAS NO 946610-68-0 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and side-chain protection in complex molecular assemblies. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing the D-isomer of hydroxyproline into peptide chains, enabling the study of structure-activity relationships.
• Pharmaceutical Intermediate: For the research and development of peptide-based drugs targeting various diseases, where the Boc-protecting group offers orthogonal deprotection strategies.
• Bioconjugation & Probe Development: Used in creating labeled peptides or affinity probes for biochemical and diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent in organic and medicinal chemistry laboratories for synthesizing custom peptides and studying collagen-like structures.
• Peptidomimetic Design: Facilitates the creation of metabolically stable peptide analogs by incorporating non-natural amino acid scaffolds.

Basic Information

Product Name	Boc-D-Hyp-Oh
CAS No.	946610-68-0
Molecular Formula	C₁₀H₁₇NO₅
Molecular Weight	231.25 g/mol
Synonyms	(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; (4R)-Boc-D-hydroxyproline; Boc-D-4-hydroxyproline; Boc-trans-4-hydroxy-D-proline; tert-Butyloxycarbonyl-D-4-hydroxyproline; N-Boc-D-hydroxyproline; N-tert-Butoxycarbonyl-D-4-hydroxyproline; D-Hyp(Boc)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Hyp-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. We provide Certificates of Analysis (COA) with detailed results for Assay (HPLC), Optical Rotation, and Residual Solvents, ensuring compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-70° to -76° (c=1 in Acetic Acid)
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.