Description

Pentafluorophenyl 2-Pyridin-4-Ylpyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate and building block characterized by its unique heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, enabling the synthesis of novel, complex molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing targeted molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and develop new drug candidates.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides, fungicides, or insecticides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Material Science: Potential precursor for the synthesis of specialty polymers or organic electronic materials due to its aromatic and fluorinated components.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	Pentafluorophenyl 2-Pyridin-4-Ylpyrimidine-5-Carboxylate
CAS No.	946409-27-4
Molecular Formula	C17H7F5N3O2
Molecular Weight	395.26 g/mol
Synonyms	2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 2-(4-pyridyl)pyrimidine-5-carboxylate; 4-Pyridyl-2-pyrimidine-5-carboxylic acid pentafluorophenyl ester; 5-(Pentafluorophenoxycarbonyl)-2-(4-pyridyl)pyrimidine; CAS 946409-27-4
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 2-Pyridin-4-Ylpyrimidine-5-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.