Description

tert-Butyl 4-Chloro-5,6-Dihydropyrido[4',3':4,5]Thieno[2,3-D]Pyrimidine-7(8H)-Carboxylate7(6H)-Carboxylic Acid CAS NO 946198-89-6 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in the development of kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and anti-inflammatory drug candidates.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing novel kinase inhibitors, targeting specific enzymes involved in cell signaling pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in route scouting and process optimization for the efficient, large-scale manufacturing of target drug molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	tert-Butyl 4-Chloro-5,6-Dihydropyrido[4',3':4,5]Thieno[2,3-D]Pyrimidine-7(8H)-Carboxylate7(6H)-Carboxylic Acid
CAS No.	946198-89-6
Molecular Formula	C19H20ClN3O4S
Molecular Weight	421.90 g/mol
Synonyms	4-Chloro-5,6-dihydro-8H-thieno[2,3-d]pyrido[4',3':4,5]pyrimidine-7-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 4-chloro-5,6-dihydro-8H-thieno[2,3-d]pyrido[4',3':4,5]pyrimidine-7-carboxylate; 946198-89-6; BOC-protected thienopyridopyrimidine intermediate; 4-Chloro-thieno[2,3-d]pyrido[4',3':4,5]pyrimidine-7-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-Chloro-5,6-Dihydropyrido[4',3':4,5]Thieno[2,3-D]Pyrimidine-7(8H)-Carboxylate7(6H)-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.