Description

(R)-Methyl 2-((2-Chloro-5-Nitropyrimidin-4-Yl)(Isopropyl)Amino)Butanoate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, structurally defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. Pharmaceutical R&D teams and fine chemical manufacturers need this material for the synthesis of complex drug candidates, where its specific configuration is essential for biological activity and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) where the (R)-configuration is pharmacologically required.
• Preclinical & Clinical Trial Material: Serves as a critical raw material for producing batches of investigational drugs for non-clinical and clinical studies.
• Process Chemistry Development: Employed by process chemists to develop and optimize scalable, cost-effective synthetic routes for new pharmaceuticals.
• Asymmetric Synthesis: Utilized in reactions that construct molecules with specific handedness, leveraging its existing stereocenter.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of pharmaceutical compounds.

Basic Information

Product Name	(R)-Methyl 2-((2-Chloro-5-Nitropyrimidin-4-Yl)(Isopropyl)Amino)Butanoate
CAS No.	946161-16-6
Molecular Formula	C12H17ClN4O4
Molecular Weight	316.74 g/mol
Synonyms	Methyl (2R)-2-[[(2-chloro-5-nitropyrimidin-4-yl)-propan-2-yl]amino]butanoate; (R)-Methyl 2-((2-Chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate; Butanoic acid, 2-[(2-chloro-5-nitropyrimidin-4-yl)(1-methylethyl)amino]-, methyl ester, (2R)-; UNII-8S7T5K6Q0K; 8S7T5K6Q0K; SCHEMBL23346877; DTXSID60677623; (R)-2-((2-Chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-((2-Chloro-5-Nitropyrimidin-4-Yl)(Isopropyl)Amino)Butanoate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch. We support development with specifications that can align with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.