Description

2-(Bromomethyl)-5-Fluorobenzaldehyde is a versatile and highly reactive bifunctional aromatic building block. This compound is valued for its dual functionality, featuring both an aldehyde group and a bromomethyl group on a fluorinated benzene ring, enabling diverse chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of fluorinated compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom and reactive sites enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of fluorinated organic frameworks, polymers, and liquid crystals with unique electronic and physical properties.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Nucleophilic Substitution: The reactive benzyl bromide moiety allows for facile nucleophilic substitution with amines, thiols, and alkoxides to introduce diverse functionalities.

Basic Information

Product Name	2-(Bromomethyl)-5-Fluorobenzaldehyde
CAS No.	945995-09-5
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	5-Fluoro-2-(bromomethyl)benzaldehyde; 2-Bromomethyl-5-fluorobenzaldehyde; 5-Fluorobenzaldehyde, 2-(bromomethyl)-; 2-(Bromomethyl)-5-fluorobenzenecarboxaldehyde; α-Bromo-5-fluoro-o-tolualdehyde; 5-Fluoro-2-formylbenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-Fluorobenzaldehyde is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.