Description

4-Chloro-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique trifluoroethoxy and biphenyl motifs.
• API Development: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects.

Basic Information

Product Name	4-Chloro-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine
CAS No.	945978-64-3
Molecular Formula	C18H12ClF4N3O
Molecular Weight	397.75 g/mol
Synonyms	4-Chloro-6-[(1R)-2,2,2-trifluoro-1-(3'-fluoro-4-biphenylyl)ethoxy]-2-pyrimidinamine; 2-Pyrimidinamine, 4-chloro-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-; BMS-A; (R)-4-Chloro-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.