Description

4-(6-Chloro-Pyrimidin-4-Yl)-1-Methyl-Piperazin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining pyrimidine and piperazinone moieties. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, custom synthesis laboratories, and pharmaceutical companies engaged in the development of new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates and investigational new drugs (INDs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: A key building block in the production route for complex target molecules, particularly kinase inhibitors and other small-molecule therapeutics.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom chemical synthesis and process development for the pharmaceutical industry.
• Biochemical Research: Employed in the development of chemical probes and tool compounds for biological pathway analysis and target validation.

Basic Information

Item	Details
Product Name	4-(6-Chloro-Pyrimidin-4-Yl)-1-Methyl-Piperazin-2-One
CAS No.	945896-90-2
Molecular Formula	C9H11ClN4O
Molecular Weight	226.66 g/mol
Synonyms	1-Methyl-4-(6-chloropyrimidin-4-yl)piperazin-2-one; 4-(6-Chloro-4-pyrimidinyl)-1-methyl-2-piperazinone; 6-Chloro-4-(4-methyl-3-oxopiperazin-1-yl)pyrimidine; 945896-90-2; 4-(6-Chloropyrimidin-4-yl)-1-methylpiperazin-2-one; 1-Methyl-4-(6-chloro-4-pyrimidinyl)-2-piperazinone
EINECS	Contact for details

Quality Control

Our 4-(6-Chloro-Pyrimidin-4-Yl)-1-Methyl-Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The material may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.