Description

[1-(2-Chloropyrimidin-4-Yl)Piperidin-3-Yl]Methanol is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted small-molecule drugs, particularly in oncology and central nervous system (CNS) research.
• Kinase Inhibitor Development: Serves as a core scaffold for constructing potent and selective kinase inhibitors, a major class of modern therapeutics.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate efficacy and safety profiles.
• Chemical Biology Probes: Employed in the development of chemical probes for studying specific biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	[1-(2-Chloropyrimidin-4-Yl)Piperidin-3-Yl]Methanol
CAS No.	945895-50-1
Molecular Formula	C10H12ClN3O
Molecular Weight	225.68 g/mol
Synonyms	1-(2-Chloropyrimidin-4-yl)piperidin-3-ylmethanol; 3-(Hydroxymethyl)-1-(2-chloropyrimidin-4-yl)piperidine; (1-(2-Chloropyrimidin-4-yl)piperidin-3-yl)methanol; 1-(2-Chloro-4-pyrimidinyl)-3-piperidinemethanol; 945895-50-1; 1-(2-Chloropyrimidin-4-yl)piperidine-3-methanol
EINECS	Contact for details

Quality Control

Our [1-(2-Chloropyrimidin-4-Yl)Piperidin-3-Yl]Methanol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects requiring standards aligned with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.