Description

1-(2-Chloropyrimidin-4-yl)piperidin-3-ol (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate featuring a chloropyrimidine core linked to a substituted piperidine ring. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing kinase inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Serves as a core scaffold for constructing potent and selective kinase inhibitors due to its privileged heterocyclic structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Bioconjugation & Probe Synthesis: The reactive chlorine atom allows for further functionalization, making it suitable for creating chemical probes and labeled compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(2-Chloropyrimidin-4-yl)piperidin-3-ol (Saltdata: Free)
CAS No.	945895-48-7
Molecular Formula	C9H10ClN3O
Molecular Weight	211.65 g/mol
Synonyms	3-Piperidinol, 1-(2-chloro-4-pyrimidinyl)-; 1-(2-Chloro-4-pyrimidinyl)-3-piperidinol; 1-(2-Chloropyrimidin-4-yl)piperidin-3-ol; 945895-48-7; 1-(2-Chloro-pyrimidin-4-yl)-piperidin-3-ol; 3-Hydroxy-1-(2-chloropyrimidin-4-yl)piperidine
EINECS	Contact for details

Quality Control

Our 1-(2-Chloropyrimidin-4-yl)piperidin-3-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.