Description

tert-Butyl [1-(2-Chloropyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a chloropyrimidine core and a protected pyrrolidine amine. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted therapeutic agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Kinase Inhibitor Development: Used in the research and production of small molecule kinase inhibitors, leveraging the chloropyrimidine moiety as a hinge-binding motif.
• Proteolysis Targeting Chimera (PROTAC) Linker Component: Incorporated into bifunctional molecules to facilitate targeted protein degradation.
• Chemical Biology Research: Employed as a tool compound for studying enzyme function and cellular signaling processes.
• Process Chemistry & Scale-Up: Serves as a critical intermediate during the optimization and commercial-scale manufacturing of novel drug candidates.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for client projects.

Basic Information

Product Name	tert-Butyl [1-(2-Chloropyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate
CAS No.	945895-40-9
Molecular Formula	C14H19ClN4O2
Molecular Weight	310.78 g/mol
Synonyms	1-(2-Chloropyrimidin-4-yl)pyrrolidin-3-yl carbamic acid tert-butyl ester; tert-Butyl N-[1-(2-chloropyrimidin-4-yl)pyrrolidin-3-yl]carbamate; 1-(2-Chloro-4-pyrimidinyl)-3-pyrrolidinol, 1,1-dimethylethyl carbamate (9CI); BOC-3-amino-1-(2-chloropyrimidin-4-yl)pyrrolidine; 4-(3-((tert-Butoxycarbonyl)amino)pyrrolidin-1-yl)-2-chloropyrimidine; 2-Chloro-4-(3-((tert-butoxycarbonyl)amino)pyrrolidin-1-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl [1-(2-Chloropyrimidin-4-Yl)Pyrrolidin-3-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.