Description

4-(2-Chloro-Pyrimidin-4-Yl)-Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidine-benzonitrile core structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides.
• Chemical Research: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies.
• Material Science: Potential building block for organic electronic materials and ligands for metal-organic frameworks (MOFs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(2-Chloro-Pyrimidin-4-Yl)-Benzonitrile
CAS No.	945756-16-1
Molecular Formula	C11H6ClN3
Molecular Weight	215.64 g/mol
Synonyms	4-(2-Chloropyrimidin-4-yl)benzonitrile; 2-Chloro-4-(4-cyanophenyl)pyrimidine; Benzonitrile, 4-(2-chloro-4-pyrimidinyl)-; 945756-16-1; 4-(2-Chloropyrimidin-4-yl)benzonitrile; 4-(2-Chloro-4-pyrimidinyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Pyrimidin-4-Yl)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.