Description

2-Di(tert-Butyloxycarbonyl)-L-Homoserine tert-Butyl Ester is a high-purity, Boc-protected amino acid derivative essential for advanced peptide synthesis. This compound provides critical orthogonality and stability during solid-phase and solution-phase peptide coupling reactions, enabling the construction of complex biomolecules. It is a key building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides and protein mimetics.

Application

• Pharmaceutical Intermediates: Serves as a crucial protected homoserine derivative in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a building block in both SPPS (Solid-Phase Peptide Synthesis) and solution-phase methodologies to incorporate homoserine residues.
• Research & Development: Enables medicinal chemistry research for drug discovery programs targeting various diseases.
• Bioconjugation: Acts as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify new bioactive compounds.

Basic Information

Product Name	2-Di(tert-Butyloxycarbonyl)-L-Homoserine tert-Butyl Ester
CAS No.	945744-04-7
Molecular Formula	C19H33NO7
Molecular Weight	387.47 g/mol
Synonyms	Boc-Homoserine(Boc)-OtBu; L-Homoserine, N2,O-bis(1,1-dimethylethyl) N-(1,1-dimethylethoxy)carbonyl-; (2S)-2,4-Bis[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester; N2,O-Bis-Boc-L-homoserine tert-butyl ester; Boc-Hse(Boc)-OtBu; tert-Butyl (2S)-2,4-bis[(tert-butoxycarbonyl)amino]butanoate
EINECS	Contact for details

Quality Control

Our 2-Di(tert-Butyloxycarbonyl)-L-Homoserine tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.