Description

n-tert-Butyloxycarbonyl-L-(p-Bromomethyl)Phenylalanine Methyl Ester is a protected amino acid derivative that serves as a crucial building block in advanced organic synthesis. Its value lies in its dual functionality, offering both a Boc-protected amine and a reactive bromomethyl group for further elaboration under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the synthesis of peptide-based drugs, enzyme inhibitors, and other complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of novel peptides and peptidomimetics.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting specific enzymes like HIV protease.
• Chemical Biology Probes: Enables the site-specific incorporation of labels or functional groups into peptides for studying protein-protein interactions.
• Linker Molecule Synthesis: The reactive bromomethyl group facilitates conjugation chemistry, useful in creating antibody-drug conjugates (ADCs) or peptide-drug conjugates.
• Combinatorial Chemistry: A valuable scaffold in libraries for high-throughput screening to discover new lead compounds.
• Academic & Industrial R&D: Fundamental reagent for exploring new synthetic methodologies and developing novel therapeutic candidates.

Basic Information

Item	Details
Product Name	n-tert-Butyloxycarbonyl-L-(p-Bromomethyl)Phenylalanine Methyl Ester
CAS No.	945245-48-7
Molecular Formula	C16H22BrNO4
Molecular Weight	372.26 g/mol
Synonyms	Boc-L-Phe(4-CH2Br)-OMe; Boc-Phe(4-BrCH2)-OMe; (2S)-3-[4-(Bromomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid methyl ester; Methyl N-[(tert-butoxy)carbonyl]-4-(bromomethyl)-L-phenylalaninate; Boc-L-4'-(Bromomethyl)phenylalanine methyl ester; L-Phenylalanine, 4-(bromomethyl)-, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-Phe(4-CH2Br)-OCH3
EINECS	Contact for details

Quality Control

Our n-tert-Butyloxycarbonyl-L-(p-Bromomethyl)Phenylalanine Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and cGMP manufacturing. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.