Description

3-(2-Chloro-5-Methylpyrimidin-4-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate featuring a unique indole-pyrimidine hybrid structure. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The core structure is highly relevant for the research and development of novel kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes to study biological processes and identify new drug targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	3-(2-Chloro-5-Methylpyrimidin-4-Yl)-1H-Indole
CAS No.	945016-62-6
Molecular Formula	C13H10ClN3
Molecular Weight	243.69 g/mol
Synonyms	1H-Indole, 3-(2-chloro-5-methyl-4-pyrimidinyl)-; 3-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole; 2-Chloro-5-methyl-4-(1H-indol-3-yl)pyrimidine; 4-(1H-Indol-3-yl)-2-chloro-5-methylpyrimidine; 945016-62-6; CAS-945016-62-6
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-5-Methylpyrimidin-4-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with the standards expected for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.